SUPERFUND BASIC RESEARCH PROGRAM

(Application to be submitted April 2008, proposed)
In collaboration with individuals at Vanderbilt University and at Oak Ridge National Laboratory, a new Superfund Basic Research Program application is being developed for submission to the NIEHS in April 2008 (PI: Dr. Michael Aschner). This research and training program will focus on mechanisms of susceptibility to mercury toxicity utilizing a number of powerful genetic models including mouse, fish, the nematode Caenorhabditis elegans, and bacteria. Of the eight projects currently included in the proposal, seven will focus on the effects of methylmercury (MeHg) in the central nervous system, while the remaining project deals with renal damage resulting from exposure to inorganic mercury. The development of the Superfund proposal has provided a mechanism for regular meetings in the area of metal neurotoxicity, including biweekly videoconferences between Vanderbilt University and Oak Ridge National Laboratory.